IFNGR1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IFNGR1 (Interferon Gamma Receptor 1, also known as CD119; IFNGR; IMD27A; IMD27B), located on 6q23.3, is a Protein Coding gene. The gene produces a 54405 Da protein composed of 489 amino acids. IFNGR1 is the ligand-binding subunit. Sequence analysis predicted that the IFNGR1 protein contains an N-terminal signal peptide, 7 potential N-linked glycosylation sites, several Ser- and Thr-rich regions, a transmembrane domain, and an approximately 223-residue cytoplasmic portion. Diseases such as Immunodeficiency 27A and Immunodeficiency 27B are associated with IFNGR1.

IFNGR1 Protein (8)

    IFNGR1 Antibody (15)

      IFNGR1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      IFNGR1 cDNA Clone (52)

      NM_000416.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010511.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_053783.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_002803880.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      IFNGR1 Lysate (8)

        IFNGR1 の背景知識

        The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins do not take part in the cell signal process but have other functions such as cell adhesion. CD119 (cluster of differentiation 119), also known as IFNGR1 ( interferon-gamma receptor 1), is part of the heterodimeric gamma interferon receptor which consists of IFNGR1 (CD119) and IFNGR2. The IFNGR1 gene encodes the ligand-binding chain (alpha) of the interferon receptor while the IFNGR gene encodes the non-ligand binding partner. The ability of the interferon-γ was achieved through binding to the interferon receptor CD119. After binding, the products of activated T-lymphocytes interferon-γ exerts antiviral activity, growth inhibitory effect, and several immune- regulatory activities on a variety of cell types.

        IFNGR1 の参考文献

        • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
        • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
        • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12
        • Novick D, et al. (1987) The human interferon-gamma receptor. The journal of biological chemistry. 262 (18): 8483-7

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