IFITM2 (Interferon Induced Transmembrane Protein 2) is a Protein Coding gene. The encoded protein IFITM2 belongs to the CD225/Dispanin family. IFITM2 knockdown decreased GC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition in vitro. And IFITM2 expression was in part induced by insulin-like growth factor (IGF) 1 via IGF1 receptor/signal transducer and activator of transcription 3 signaling. Furthermore, IFITM2 regulated interleukin-6 expression and secretion, which in turn increased IFITM2 expression. Silencing of IFITM2 expression suppressed tumor growth and lung metastasis in vivo. That IFITM2 is a novel prognostic biomarker and regulator of GC progression. IFITM2 is widely expressed in the appendix, spleen, and other tissues. Diseases associated with IFITM2 include Cycloplegia and Influenza.