ICAM4 Proteins, cDNA Clones Research Reagents

ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group, also known as LW; CD242), located on 19p13.2, is a Protein Coding gene. The gene produces a 29265 Da protein composed of 271 amino acids. ICAM4 is a member of the immunoglobulin (Ig) gene superfamily and encodes the Landsteiner-Wiener (LW) blood group antigens. ICAM4 binds to the leukocyte adhesion LFA-1 protein. Diseases such as Blood Group System, Landsteiner-Wiener and Anemia, Congenital Dyserythropoietic, Type Iv are associated with ICAM4. The related pathways of ICAM4 include the Degradation of the extracellular matrix and the Autophagy Pathway.

ICAM4 Protein (1)

    ICAM4 cDNA Clone (14)


    クローニングベクター cDNA 製品

    In lentiviral vector


    In expression vector

    ICAM4 qPCR Primer (1)

    ICAM4 Lysate (1)

      ICAM4 の背景知識

      ICAM4, also known as CD242, is a member of the immunoglobulin superfamily, the ICAM family. ICAM4 contains 2 Ig-like C2-type (immunoglobulin-like) domains. It is similar to the intercellular adhesion molecule (ICAM) protein family. ICAM4 binds to the leukocyte adhesion LFA-1 protein. ICAM4's first reported receptors were CD11a/CD18 and CD11b/CD18. ICAM4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM4 demonstrated that both its domains contain binding sites for CD11c/CD18. CD11c/CD18 is expressed on macrophages in the spleen and bone marrow. Inhibition of erythrophagocytosis by anti-ICAM4 and anti-integrin antibodies suggests a role for these interactions in the removal of senescent red cells.

      ICAM4 の参考文献

      • Gorst DW. et al., 1980, Vox Sanguinis. 38 (2): 99-105.
      • Vos GH. et al., 1973, Blood. 42 (3): 445-53.
      • Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.
      • Daniels G. et al., 2002, Transfusion Medicine. 12 (5): 287-95.

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