ICAM-2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

ICAM2 (Intercellular Adhesion Molecule 2, also known as CD102), located on 17q23.3, is a Protein Coding gene. The gene produces a 30654 Da protein composed of 275 amino acids. ICAM2 is an integral membrane protein that has 2 immunoglobulin-like domains, unlike ICAM1, which has 5. It belongs to the ICAM family. As the second ligand of leukocyte function-associated antigen-1, ICAM-2 functions as a costimulatory molecule for effector cells. Diseases such as Leukocyte Adhesion Deficiency, Type I, and Colon Carcinoma In Situ are associated with ICAM2.

ICAM-2 Protein (4)

    ICAM-2 Antibody (9)

      ICAM-2 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      ICAM-2 cDNA Clone (39)

      NM_000873.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010494.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001007725.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      ICAM-2 Lysate (4)

        ICAM-2 の背景知識

        Intercellular adhesion molecule 2 (ICAM-2, CD102), belongs to the ICAM family consisting of three members identified as ligands for integrin receptors. It is a type I transmembrane glycoprotein with two Ig-like C2-type domains and binds to the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). As the second ligand of leukocyte function-associated antigen-1, ICAM-2 functions as a costimulatory molecule for effector cells. ICAM-2 is mainly expressed on vascular endothelial and hematopoietic cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocyte with other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity, and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relationship with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in the diagnosis of trichinosis recent infections, and in monitoring the prognosis and response to treatment.

        ICAM-2 の参考文献

        • Weber KS, et al. (2004) Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN. Inflammation. 28(4): 177-88.
        • Tanaka H, et al. (2004) ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma. Clin Cancer Res. 10(14): 4885-92.
        • Younis AI, et al. (2005) Intercellular adhesion molecule-2 (ICAM-2) in experimental trichinosis. J Egypt Soc Parasitol. 35(3): 1019-26.

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