HTR4/5-HT4 Antibodies, cDNA Clones Research Reagents

HTR4 (5-Hydroxytryptamine Receptor 4, also known as 5-HT4; 5-HT4R), located on 5q32, is a Protein Coding gene. The gene produces a 43761 Da protein composed of 388 amino acids. HTR4 is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Diseases such as Irritable Bowel Syndrome and Constipation are associated with HTR4. The related pathways of HTR4 include Neuroscience and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics.

HTR4/5-HT4 Antibody (1)

    HTR4/5-HT4 cDNA Clone (26)

    NM_001040169.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_008313.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    HTR4/5-HT4 の背景知識

    HTR4 (5-Hydroxytryptamine Receptor 4, also known as 5-HT4R) is a Protein Coding gene. This gene is a member of the family of serotonin receptors, which are G protein-coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The encoded protein is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. 5-HTR3 and 5-HTR4 were located in cardiac mitochondria, and regulated mitochondrial activities and cellular functions. Noncoding variants in HTR4 are associated with pulmonary function in human GWASs. The HTR4 gene is located in a region previously linked to an increased risk of asthma and atopy. SNP and haplotypes of the HTR4 gene were associated with the asthma phenotype and genetic variation of HTR4 may affect susceptibility to the development of asthma.

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