HSC70 Proteins, cDNA Clones Research Reagents

HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8, also known as LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; LAP-1; NIP71; HEL-33; HSPA10; HEL-S-72p), located on 11q24.1, is a Protein Coding gene. The gene produces a 70898 Da protein composed of 646 amino acids. HSPA8 is constitutively expressed and performs functions related to normal cellular processes. This protein binds to nascent polypeptides to facilitate correct protein folding. HSPA8 also functions as an ATPase in the disassembly of clathrin-coated vesicles during the transport of membrane components through the cell.

HSC70 Protein (1)

    HSC70 cDNA Clone (59)

    NM_006597.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_031165.5

    クローニングベクター cDNA 製品

    In lentiviral vector

    BC061547.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001261657.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_005619650.1

    クローニングベクター cDNA 製品

    HSC70 の背景知識

    HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised of both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 belongs to the heat-shock cognate subgroup. Members of the human heat-shock protein multigene family have several highly conserved proteins with structural and functional properties in common but vary in the extent of their inducibility in response to metabolic stress. HSPA8 is constitutively expressed and performs functions related to normal cellular processes. This protein binds to nascent polypeptides to facilitate correct protein folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during the transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date. HSPA8 acts as a repressor of transcriptional activation. It inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing with the co-chaperones. It also is an ATPase that works with Auxilin to remove clathrin-coated vesicles. In neurons, synaptojanin is also an important protein involved in vesicle uncoating.

    HSC70 の参考文献

    • Santacruz H, et al. (1997) Molecular characterization of a heat shock cognate cDNA of zebrafish, hsc70, and developmental expression of the corresponding transcripts. Dev Genet. 21:223-33.
    • Harhay G P, et al. (2005) Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 6: 166.
    • Goldfarb S, et al. (2006) Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels. Proc Natl Acad Sci. 103(15):5817-22.

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