HOXA1 Proteins, cDNA Clones Research Reagents

HOXA1 (Homeobox A1, also known as BSAS; HOX1; HOX1F), located on 7p15.2, is a Protein Coding gene. The gene produces a 36641 Da protein composed of 335 amino acids. HOXA1 may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. HOXA1 and HOXA2, are required for proper patterning of the early mouse hindbrain and the associated neural crest. Diseases such as Athabaskan Brainstem Dysgenesis Syndrome and Microtia, Hearing Impairment, And Cleft Palate are associated with HOXA1.

HOXA1 Protein (1)

    HOXA1 cDNA Clone (2)

    NM_005522.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    HOXA1 の背景知識

    Homeobox protein Hox-A1 is a transcription factor encoded by the HOXA1 gene. This gene is one of the four types of homeobox genes each of which contains a homeobox DNA sequence that codes for the homeodomain, a region of 60 amino acids responsible for the DNA binding exhibited by these homeobox proteins. These Homeobox genes are essential metazoan genes as they determine the identity of embryonic regions along the anterior-posterior axis. The homeobox protein Hox-A1 may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Early in its development, the vertebrate hindbrain is transiently subdivided into a series of compartments called rhombomeres. Genes have been identified whose expression patterns distinguish these cellular compartments. Two of these genes, Hoxa1 and Hoxa2, are required for proper patterning of the early mouse hindbrain and the associated neural crest. It has been detected HOXA1 expression in a variety of human breast cancer lesions, suggesting that HOXA1 may be required for the establishment of breast cancer cell phenotype.

    HOXA1 の参考文献

    • Barrow JR, et al. (2000) Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. Development. 127: 933-44.
    • Hong YS, et al. (1995) Structure and function of the HOXA1 human homeobox gene cDNA. Gene. 159 (2): 209-14.
    • Gavalas A, et al. (2001) Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest. Development. 128: 3017-27.

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