High mobility group box protein 3 (HMGB3) regulates proliferation and inflammatory response in vertebrates. High mobility group box 3 (HMGB3), a member of the high-mobility group box (HMGB) family, was reported to be over-expressed in gastric carcinoma and bladder cancer, affect tumor initiation and progression. HMGB3 may serve as an oncoprotein and could be used as a potential prognostic marker in colorectal cancer (CRC). HMBG3 may be a potential molecular marker for predicting the prognosis of esophageal squamous cell carcinoma (ESCC) patients. HMGB3 may serve as an important oncoprotein and indicate that overexpression of HMGB3 in Human urinary bladder cancer (UBC) could be used as a potential prognostic marker.