HK3 Proteins, cDNA Clones Research Reagents

HK3 (Hexokinase 3, also known as HXK3; HKIII), located on 5q35.2, is a Protein Coding gene. The gene produces a 99025 Da protein composed of 923 amino acids. Similar to hexokinases-1 and hexokinases-2, this allosteric enzyme is inhibited by its product glucose 6-phosphate. This encoded protein has over 50% identity with human HK1 and HK2. There is 84.7% identity between the amino acid sequences of human and rat hexokinase-3. The related pathways of HK3 include Glucose metabolism and Galactose metabolism.

HK3 Protein (1)

    HK3 cDNA Clone (15)

    NM_002115.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    HK3 qPCR Primer (1)

    HK3 Lysate (1)

      HK3 の背景知識

      Hexokinase-3, also known as Hexokinase type III, HKIII, and HK3, is a protein that belongs to the hexokinase family. Hexokinase-3 / HK3 is an enzyme that in humans is encoded by the HK2 gene. Hexokinases phosphorylate glucose to produce glucose 6-phosphate, committing glucose to the glycolytic pathway. In mammalian tissues, hexokinase exists as four isoenzymes encoded by distinct genes. These proteins are homologous and are organized in two homologous domains, except for hexokinase type IV which has only one. This organization is believed to be the result of a duplication and tandem fusion event involving the gene encoding for the ancestral hexokinase. The gene encodes hexokinase-3. Similar to hexokinases-1 and hexokinases-2, this allosteric enzyme is inhibited by its product glucose 6-phosphate.

      HK3 の参考文献

      • Palma F. et al., 1996, Mol Cell Biochem. 155: 23-9.
      • Furuta H. et al.,1996, Genomics. 36 (1): 206-9.
      • Colosimo A. et al.,1996, Cytogenet Cell Genet. 74 (3): 187-8.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.