Histone H1 Proteins, Antibodies, cDNA Clones Research Reagents

H1-0 (H1.0 Linker Histone, also known as H10; H1.0; H1F0; H1FV), located on 22q13.1, is a Protein Coding gene. The gene produces a 20863 Da protein composed of 194 amino acids. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division. Diseases such as Hyperoxaluria, Primary, Type I and Spherocytosis, Type 1 are associated with H1-0. The related pathways of H1-0 include Activation of cAMP-Dependent PKA and Granzyme-A Pathway.

Histone H1 Protein (1)

    Histone H1 Antibody (1)

      Histone H1 cDNA Clone (32)

      NM_005318.3

      In lentiviral vector

      In expression vector

      NM_008197.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001088913.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      Histone H1 の背景知識

      H1 histone family, member 0 (H1F0) is a member of the H1 histone family of nuclear proteins which are a component of chromatin in eukaryotic cells. It's involved in maintaining the structure of chromatin by packing the "beads on a string" sub-structure into a high order structure. The lysine-rich H1 histone family in mammals includes eleven members. In higher eukaryotes, all H1 variants have the same general structure, consisting of a central conserved globular domain and less conserved N-terminal and C-terminal tails. These tails are moderately conserved among species, but differ among variants, suggesting a specific function for each H1 variant. Studies on the role of particular subtypes at specific developmental stages in lower eukaryotes, but also in vertebrates suggest that specific subtypes of H1 participate in particular systems of gene regulation.

      Histone H1 の参考文献

      • Ramakrishnan V, et al. (1993) Crystal structure of globular domain of histone H5 and its implications for nucleosome binding. Nature. 362 (6417): 219-23.
      • Happel N, et al. (2009) Histone H1 and its isoforms: contribution to chromatin structure and function. Gene. 431 (1-2): 1-12.
      • Izzo A, et al. (2008) The histone H1 family: specific members, specific functions. Biol Chem. 389 (4): 333-43.

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