HIPK2 Antibodies, cDNA Clones Research Reagents

HIPK2 (Homeodomain Interacting Protein Kinase 2, also known as PRO0593), located on 7q34, is a Protein Coding gene. The gene produces a 130966 Da protein composed of 1198 amino acids. HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors. The HIPK2 protein is 96% identical to the mouse protein and has a CD95-binding site between residues 754 and 899. Diseases such as Hypoxia and Keratoacanthoma are associated with HIPK2. The related pathways of HIPK2 include Apoptosis Modulation and Signaling and Regulation of TP53 Activity.

HIPK2 Antibody (2)

    HIPK2 cDNA Clone (15)


    クローニングベクター cDNA 製品

    In lentiviral vector

    HIPK2 qPCR Primer (1)

    HIPK2 の背景知識

    HIPK2 (Homeodomain Interacting Protein Kinase 2) is a Protein Coding gene. This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. There is a regulated interaction between the serine/threonine kinase HIPK2 and the ubiquitin E3 ligase Siah2 as a mechanism controlling the hypoxic response. HIPK2 has an important role as a negative regulator of gene expression, its elimination from promoter-associated repressor complexes allows the induction of a substantial fraction of hypoxia-induced genes. The tumor suppressor HIPK2 is an important regulator of cell death induced by DNA damage. HIPK2 is widely expressed in the brain, kidney, and other tissues. Diseases associated with HIPK2 include Hypoxia and Keratoacanthoma.

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