HGF Activator/HGFA Proteins, Antibodies, cDNA Clones Research Reagents

HGFAC (HGF Activator, also known as HGFA), located on 4p16.3, is a Protein Coding gene. The gene produces a 70682 Da protein composed of 655 amino acids. The encoded protein is a serum-derived serine protease and belongs to the peptidase family S1. HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form. Diseases such as Deafness, Autosomal Recessive 97 are associated with HGFAC. The related pathways of HGFAC include Signaling by GPCR and Development HGF signaling pathway.

HGF Activator/HGFA Protein (1)

    HGF Activator/HGFA Antibody (4)

      HGF Activator/HGFA cDNA Clone (26)

      NM_001528.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_019447.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      HGF Activator/HGFA Lysate (1)

        HGF Activator/HGFA の背景知識

        HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is cleaved by thrombin or thermolysin through the endoproteolytic process and forms an active heterodimer linked by a disulfide bond. In turn, the active protease can be inhibited by HGFA inhibitors (HAIs) including HAI-1 and HAI-2. Besides, the HGFA zymogen acquires a strong affinity upon activation and thus may ensure the local action in tissue regeneration in the liver, kidney, and skin. It has been reported that activation of HGF is a critical limiting step in the HGF/SF-induced signaling pathway mediated by Met, and accordingly, aberrant expression of HGFA is implicated in tumorigenesis and progression.

        HGF Activator/HGFA の参考文献

          1.  Shimomura, T. et al., 1993, J. Biol. Chem. 268: 22927-22932.

          2.  Miyazawa, K. et al., 1996, J. Biol. Chem. 271 : 3615-3618.

          3.  Shia, S. et al., 2005, J. Mol. Biol. 346: 1335-1349.

          4.  Kataoka, H. et al., 2000, J. Biol. Chem. 275: 40453-40462.

          5.  Tjin, E.P. et al., 2006, Blood. 107: 760-768.

          6.  Kitajima, Y. et al., 2000, Cancer. Res. 60: 6148-6159.

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