HK1 (Hexokinase 1) is a Protein Coding gene. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. The encoded protein belongs to the hexokinase family. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. The HK1-dependent glycolysis, under the regulation of mTORC1, represents a critical metabolic pathway for NLRP3 inflammasome activation. The upregulation of HK1-dependent glycolysis by mTORC1 regulates NLRP3 inflammasome activation. HK1 is widely expressed in the heart, esophagus, and other tissues. Diseases associated with HK1 include Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency and Neuropathy, Hereditary Motor And Sensory, Russe Type.