Hexokinase 1/HK1 Antibodies, cDNA Clones Research Reagents

HK1 (Hexokinase 1, also known as HK; HKD; HKI; HXK1; RP79; HMSNR; HK1-ta; HK1-tb; HK1-tc; NEDVIBA; hexokinase), located on 10q22.1, is a Protein Coding gene. The gene produces a 102486 Da protein composed of 917 amino acids. The HK1-dependent glycolysis, under the regulation of mTORC1, represents a critical metabolic pathway for NLRP3 inflammasome activation. Diseases such as Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency and Neuropathy, Hereditary Motor And Sensory, Russe Type are associated with HK1. The related pathways of HK1 include Glucose metabolism and Galactose metabolism.

Hexokinase 1/HK1 Antibody (2)

    Hexokinase 1/HK1 cDNA Clone (30)

    NM_000188.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001146100.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    Hexokinase 1/HK1 の背景知識

    HK1 (Hexokinase 1) is a Protein Coding gene. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. The encoded protein belongs to the hexokinase family. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. The HK1-dependent glycolysis, under the regulation of mTORC1, represents a critical metabolic pathway for NLRP3 inflammasome activation. The upregulation of HK1-dependent glycolysis by mTORC1 regulates NLRP3 inflammasome activation. HK1 is widely expressed in the heart, esophagus, and other tissues. Diseases associated with HK1 include Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency and Neuropathy, Hereditary Motor And Sensory, Russe Type.

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