HEMK2 Proteins, cDNA Clones Research Reagents

N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1, also known as KMT9; MTQ2; PrmC; HEMK2; N6AMT; PRED28; C21orf127; m.HsaHemK2P), located on 21q21.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, A.thaliana, rice, and frog. The gene produces a 22957 Da protein composed of 214 amino acids. This gene encodes an N(6)-adenine-specific DNA methyltransferase. The related pathways of N6AMT1 include Viral mRNA Translation and Cytochrome P450 - arranged by substrate type.

HEMK2 Protein (1)

    HEMK2 cDNA Clone (16)

    NM_013240.5

    クローニングベクター cDNA 製品

    In lentiviral vector

    HEMK2 qPCR Primer (1)

    HEMK2 の背景知識

    N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes an N(6)-adenine-specific DNA methyltransferase. It belongs to the eukaryotic/archaeal PrmC-related family. The encoded enzyme may be involved in the methylation of release factor I during translation termination. N6AMT1 has a significant role in determining susceptibility to arsenic toxicity and carcinogenicity because of its specific activity in methylating MMAIII to DMA and other unknown mechanisms. N6AMT1 methylates the toxic inorganic arsenic (iAs) metabolite, monomethylarsonous acid (MMA), to the less toxic dimethylarsinic acid (DMA). N6AMT1 polymorphisms were associated with arsenic methylation in Andean women, independent of AS3MT.

    HEMK2 の参考文献

    • Ren X, et al. (2011) Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity. Environ Health Perspect. 119(6): 771-7.
    • Yang Z, et al. (2004) Structural characterization and comparative phylogenetic analysis of Escherichia coli HemK, a protein (N5)-glutamine methyltransferase. J Mol Biol. 340(4): 695-706.
    • Bujnicki JM, et al. (1999) Is the HemK family of putative S-adenosylmethionine-dependent methyltransferases a missing zeta subfamily of adenine methyltransferases? A hypothesis. IUBMB Life. 48(3): 247-9.

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