HDAC11 Antibodies, cDNA Clones Research Reagents

HDAC11 (Histone Deacetylase 11, also known as HD11), located on 3p25.1, is a Protein Coding gene. The gene produces a 39183 Da protein composed of 347 amino acids. HDAC11 controls DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression. The protein contains 9 deacetylase motifs shared by both class I and class II HDACs. HDAC11 has therapeutic potential for treating diabetes mellitus-associated cardiac injury. Diseases such as Bicipital Tenosynovitis and Subungual Glomus Tumor are associated with HDAC11.

HDAC11 Antibody (2)

    HDAC11 cDNA Clone (30)

    BC009676.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_144919.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    HDAC11 の背景知識

    Histone deacetylases (HDACs) are enzymes that regulate protein functions by catalyzing the removal of acetyl and acyl groups from lysine residues, which play pivotal roles in governing cell behaviors. HDAC11 knockout mice are resistant to high-fat diet-induced obesity and metabolic syndrome, suggesting that HDAC11 functions as a crucial metabolic regulator. HDAC11 is a novel regulator of obesity, with potentially important implications for obesity-related disease treatment. HDAC11 has therapeutic potential for treating diabetes mellitus-associated cardiac injury. Histone deacetylases (HDACs) are involved in multiple physical and pathological processes in classical Hodgkin lymphoma (cHL). HDAC11 was initially identified as a negative regulator of the well-known anti-inflammatory cytokine IL-10.

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