HDAC1 Antibodies, cDNA Clones Research Reagents

HDAC1 (Histone Deacetylase 1, also known as HD1; RPD3; KDAC1; GON-10; RPD3L1), located on 1p35.2-p35.1, is a Protein Coding gene. The gene produces a 55103 Da protein composed of 482 amino acids. HDAC1 is a ubiquitous deacetylase enzyme responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. Diseases such as Atrichia With Papular Lesions and Retinoblastoma are associated with HDAC1.

HDAC1 Antibody (2)

    HDAC1 cDNA Clone (30)

    NM_004964.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    BC108371

    クローニングベクター cDNA 製品

    In lentiviral vector

    HDAC1 qPCR Primer (1)

    HDAC1 の背景知識

    HDAC1 (Histone Deacetylase 1) is a Protein Coding gene. Histone Deacetylase 1 protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. HDAC1 is a ubiquitous deacetylase enzyme responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. HDAC1 is widely expressed in the lymph node, colon, and other tissues. Diseases associated with HDAC1 include Atrichia With Papular Lesions and Retinoblastoma.

    HDAC1 の参考文献

    • Beharry AW, Sandesara PB, Roberts BM, Ferreira LF, Senf SM, Judge AR. HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy. Journal of Cell Science. 2014;127(7):1441-1453.

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