HAPLN1 Proteins, cDNA Clones Research Reagents

HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1, also known as CRT1; CRTL1), located on 5q14.3, is a Protein Coding gene. The gene produces a 40166 Da protein composed of 354 amino acids. HAPLN1 stabilizes the interaction between hyaluronan (HA) and versican, two extracellular matrix components essential for cardiac development. The protein shows a striking degree of similarity to porcine, rat, and chicken link protein sequences. Diseases such as Juvenile Rheumatoid Arthritis and Cerebral Creatine Deficiency Syndrome are associated with HAPLN1.

HAPLN1 Protein (1)

    HAPLN1 cDNA Clone (28)

    NM_001884.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    AF139572.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    HAPLN1 qPCR Primer (1)

    HAPLN1 Lysate (1)

      HAPLN1 の背景知識

      Hyaluronan (HA) is a high MW glycosaminoglycan significantly involved in the formation and stability of extracellular matrix via its association with specific HA-binding proteins. HAPLN1, also known as CRTL1 (Cartilage Link Protein 1, CLP) and link protein, is a member of the HA-binding protein (hyaladherins) family, and contains a common structural domain of about 100 amino acids that is termed a Link module with two α-helices and two antiparallel β-sheets. HAPLN1/CRTL1 stabilizes the interaction between hyaluronan (HA) and versican, two extracellular matrix components essential for cardiac development. Link module superfamily can be divided into three subgroups, and the HAPLN family are C domain-type proteins that have an extended structure with one N-terminal V-type Ig-like domain followed by two link modules. In cartilage, aggrecan forms - CLP stabilized aggregates with HA that provides the tissue with its load-bearing properties. HAPLN1 is a component of the follicular matrix, was shown to enhance cumulus-oocyte complex (COC) expansion in vitro. HAPLN1 may promote periovulatory granulosa cell survival, which would facilitate their differentiation into luteal cells.

      HAPLN1 の参考文献

      • Sun GW, et al. (2003) Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells. Endocrinology. 144(3): 793-801.
      • Wirrig EE, et al. (2007) Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development. Dev Biol. 310(2): 291-303.
      • Liu J, et al. (2010) Periovulatory expression of hyaluronan and proteoglycan link protein 1 (Hapln1) in the rat ovary: hormonal regulation and potential function. Mol Endocrinol. 24(6): 1203-17.

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