HAI-2/SPINT2 Proteins, Antibodies, cDNA Clones Research Reagents

All HAI-2/SPINT2 reagents are produced in house and quality controlled, including 6 HAI-2/SPINT2 Antibody, 26 HAI-2/SPINT2 Gene, 3 HAI-2/SPINT2 Lysate, 3 HAI-2/SPINT2 Protein, 2 HAI-2/SPINT2 qPCR. All HAI-2/SPINT2 reagents are ready to use.

HAI-2/SPINT2 Protein (3)

    HAI-2/SPINT2 Antibody (6)

      HAI-2/SPINT2 cDNA Clone (26)


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      HAI-2/SPINT2 Lysate (3)

        HAI-2/SPINT2 の背景知識

        Choanal (CA) and gastrointestinal atresias (GA) are an important feature of syndromic congenital sodium diarrhea (sCSD), a disorder recently associated with mutations in the gene for serine protease inhibitor type 2 (SPINT2). The SPINT2 gene is epigenetically silenced or downregulated in human cancers, altering the balance of HGF activation/inhibition ratio, which contributes to cancer development and progression. SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase. Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation. SPINT2 (serine peptidase inhibitor Kunitz type 2), a proteolytic inhibitor of hepatocyte growth factor activator (HGFA), which has a significant role in the suppression of the HGF-MET pathway and malignant melanoma progression.

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