HADH Antibodies, cDNA Clones Research Reagents

HADH (Hydroxyacyl-CoA Dehydrogenase, also known as HAD; HCDH; HHF4; HADH1; SCHAD; HADHSC; MSCHAD), located on 4q25, is a Protein Coding gene. The gene produces a 34294 Da protein composed of 314 amino acids. HADH catalyzes the reversible dehydrogenation of 3-hydroxyacyl-CoAs to their corresponding 3-ketoacyl-CoAs with concomitant reduction of NAD to NADH and exerts its highest activity toward 3-hydroxydecanoyl-CoA. Human HADH encodes a protein composed of a 12-residue mitochondrial import signal peptide and a 302-residue mature HADH protein.

HADH Antibody (2)

    HADH cDNA Clone (32)

    NM_001184705.2

    In expression vector

    NM_008212.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_057186.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    HADH qPCR Primer (1)

    HADH の背景知識

    HADH (Hydroxyacyl-CoA Dehydrogenase, also known as HADHSC) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. HADH is a key enzyme in fatty acid oxidation. It is widely expressed in fat, kidney, and other tissues. The downregulation of HADH promotes gastric cancer progression via activation of the Akt signaling pathway. Recessive mutations in the hydroxyacyl-CoA dehydrogenase (HADH) gene encoding the enzyme 3-hydroxyacyl-CoA dehydrogenase are a rare cause of diazoxide-responsive hyperinsulinemic hypoglycemia (HH).

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