H2AFY Antibodies, cDNA Clones Research Reagents

MACROH2A1 (MacroH2A.1 Histone, also known as H2A.y; H2A/y; H2AFY; mH2A1; H2AF12M; MACROH2A1.1; macroH2A1.2), located on 5q31.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 39617 Da protein composed of 372 amino acids. Diseases such as Liebenberg Syndrome and Medulloblastoma are associated with MACROH2A1. The related pathways of MACROH2A1 include Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin Regulation / Acetylation.

H2AFY Antibody (1)

    H2AFY cDNA Clone (15)


    クローニングベクター cDNA 製品

    In lentiviral vector

    H2AFY qPCR Primer (1)

    H2AFY の背景知識

    MACROH2A1 (MacroH2A.1 Histone, also known as H2AFY) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. H2AFY is widely expressed in bone marrow, esophagus, and other tissues. Diseases associated with MACROH2A1 include Liebenberg Syndrome and Medulloblastoma. H2AFY is a potential biomarker associated with disease activity and pharmacodynamic response that may become useful for enabling disease-modifying therapeutics for Huntington's disease (HD). An important paralog of this gene is MACROH2A2.

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