GSTZ1 Proteins, Antibodies, cDNA Clones Research Reagents

GSTZ1 (Glutathione S-Transferase Zeta 1, also known as MAI; MAAI; MAAID; GSTZ1-1), located on 14q24.3, is a Protein Coding gene. The gene produces a 24212 Da protein composed of 216 amino acids. GSTZ1 catalyzes the glutathione-dependent oxygenation of dichloroacetic acid to glyoxylic acid and participates in the catabolism of phenylalanine and tyrosine. Human GSTZ1-1 was 38% and 49% identical to the carnation and C. elegans proteins, respectively. Diseases such as Maleylacetoacetate Isomerase Deficiency and Tyrosinemia, Type I are associated with GSTZ1.

GSTZ1 Protein (1)

    GSTZ1 Antibody (5)

      GSTZ1 cDNA Clone (45)

      BC001453

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010363.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001109445.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      GSTZ1 の背景知識

      GSTZ1 (Glutathione S-Transferase Zeta 1) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. GSTZ1 gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. GSTZ1 is a bifunctional protein that has minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. GSTZ1 catalyzes the glutathione-dependent oxygenation of dichloroacetic acid to glyoxylic acid. GSTZ1 participates in the catabolism of phenylalanine and tyrosine. Thus defects in GSTZ1 cause harsh metabolic disorders including alkaptonuria, phenylketonuria, and tyrosinemia.

      GSTZ1 の参考文献

      • Tong Z. et al., 1999, Chem Res Toxicol. 11 (11): 1332-8.
      • Tong Z. et al., 1999, Biochem J. 331 (2): 371-4.
      • Ketterer B. 2001, Chem Biol Interact. 138 (1): 27-42.

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