GSTM2 Proteins, Antibodies, cDNA Clones Research Reagents

GSTM2 (Glutathione S-Transferase Mu 2, also known as GST4; GSTM; GTHMUS; GSTM2-2), located on 1p13.3, is a Protein Coding gene. The gene produces a 25745 Da protein composed of 218 amino acids. GSTM2 is a cytoplasm protein that belongs to the GST superfamily and Mu family. It shares an 84.8% sequence identity with the GSTM1 protein. Diseases such as Barrett's Adenocarcinoma and Hepatocellular Carcinoma are associated with GSTM2. The related pathways of GSTM2 include Drug metabolism - cytochrome P450 and Glutathione metabolism.

GSTM2 Protein (1)

    GSTM2 Antibody (5)

      GSTM2 cDNA Clone (45)

      NM_000848

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008183.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_177426.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      GSTM2 qPCR Primer (2)

      GSTM2 の背景知識

      Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2, and GSTM2, is a cytoplasm protein that belongs to the GST superfamily and Mu family. GSTM2 / GST4 contains one GST C-terminal domain and one GST N-terminal domain. The glutathione S-transferases (GSTs) are a multigene family of enzymes largely involved in the detoxification of chemicals. Eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta. Butyrate, an important luminal component produced from the fermentation of dietary fibers, is an efficient inducer of GSTs and especially of GSTM2. Butyrate may act chemoprotective by increasing detoxification capabilities in the colon mucosa.

      GSTM2 の参考文献

      • Campbell E, et al.,1990, J Biol Chem 265 (16): 9188-93. 
      • Vorachek WR, et al.,1991, Proc Natl Acad Sci USA. 88 (10): 4443-7.
      • Ebert,M.N. et al., 2003, Carcinogenesis. 24 (10):1637-44.

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