GRK6 Proteins, cDNA Clones Research Reagents

GRK6 (G Protein-Coupled Receptor Kinase 6, also known as GPRK6), located on 5q35.3, is a Protein Coding gene. The gene produces a 65991 Da protein composed of 576 amino acids. GRK6 is a lipid-anchor protein that belongs to the protein kinase superfamily. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. GRK6 also appears to be involved in responses to morphine. The GRK6 protein is 70% identical to GRK5. Diseases such as Whim Syndrome are associated with GRK6.

GRK6 Protein (1)

    GRK6 cDNA Clone (1)

    NM_002082.4

    In expression vector

    GRK6 Lysate (1)

      GRK6 の背景知識

      G protein-coupled receptor kinase 6, also known as G protein-coupled receptor kinase GRK6, GRK6, and GPRK6, is a lipid-anchor protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRK6 / GPRK6 contains one AGC-kinase C-terminal domain, one protein kinase domain, and one RGS domain. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described. GRK6 / GPRK6 is widely expressed. GRK6 / GPRK6 silencing causes suppression of signal transducer and activator of transcription 3 (STAT3) phosphorylation associated with a reduction in MCL1 levels and phosphorylation, illustrating a potent mechanism for the cytotoxicity of GRK6 inhibition in multiple myeloma (MM) tumor cells. GRK6 also appears to be involved in responses to morphine. Inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.

      GRK6 の参考文献

      • Ghadessy,R.S. et al., 2003, Br J Pharmacol  138 (4):660-70.
      • Murga,C. et al., 2009, Brain Behav Immun. 23 (1):16-7.
      • Tiedemann,R.E. et al., 2010, Blood  115 (8):1594-604.
      • Ahmed,M.R. et al., 2010, Sci Transl Med 2 (28): 28ra28.

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