GRK5 Proteins, Antibodies, cDNA Clones Research Reagents

GRK5 (G Protein-Coupled Receptor Kinase 5, also known as GPRK5; FP2025), located on 10q26.11, is a Protein Coding gene. The gene produces a 67787 Da protein composed of 590 amino acids. GRK5 is an important regulator of GPCR function and mediates receptor desensitization, internalization, and signaling. The protein has a predicted central protein kinase catalytic domain. GRK5 shares 69% amino acid identity with IT11 (GRK4) and is also closely related to Drosophila Gprk2 and bovine rhodopsin kinase (GRK1). The related pathways of GRK5 include RET signaling and Signaling by GPCR.

GRK5 Protein (1)

    GRK5 Antibody (1)

      GRK5 cDNA Clone (30)

      NM_005308.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_018869.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      GRK5 Lysate (1)

        GRK5 の背景知識

        G protein-coupled receptor kinase 5, also known as G protein-coupled receptor kinase GRK5 and GRK5, is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRKs specifically phosphorylate agonist-occupied G protein-coupled receptors at the inner surface of the plasma membrane (PM), leading to receptor desensitization. GRKs utilize a variety of mechanisms to bind tightly, and sometimes reversibly, to cellular membranes. GRKs play an important role in mediating agonist-specific desensitization of numerous G protein-coupled receptors.
        GRK5 contains one AGC-kinase C-terminal domain, one protein kinase domain, and one RGS domain. GRK5 specifically phosphorylates the activated forms of G protein-coupled receptors. Phospholipid-stimulated autophosphorylation may represent a novel mechanism for membrane association and regulation of GRK5 activity. GRK5 deficiency significantly exaggerates microgliosis and astrogliosis in the presence of an inflammatory initiator, such as the excess fibrillar Abeta and the subsequent active inflammatory reactions. GRK5 deficiency has been linked to early Alzheimer's disease in humans and mouse models of the disease.

        GRK5 の参考文献

        • Kunapuli,P. et al., 1994, J Biol Chem. 269 (14):10209-12.
        • Millman,E.E. et al., 2004, Br J Pharmacol  141 (2):277-84.
        • Thiyagarajan,M.M. et al., 2004, J Biol Chem  279 (17):17989-95.
        • Suo,Z. et al., 2007,Neurobiol Aging. 28 (12):1873-88.
        • Li,L. et al., 2008,J Neuroinflammation. 5 :24.

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