Granzyme H Proteins, Antibodies, cDNA Clones Research Reagents

GZMH (Granzyme H, also known as CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2), located on 14q12, is a Protein Coding gene. The gene produces a 27315 Da protein composed of 246 amino acids. Human GZMH is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/natural killer (NK) compartment of the immune system. Diseases such as Lipodystrophy, Congenital Generalized, Type 2 are associated with GZMH. The related pathways of GZMH include Peptide hormone metabolism and Granzyme Pathway.

Granzyme H Protein (1)

    Granzyme H Antibody (2)

      Granzyme H cDNA Clone (13)


      クローニングベクター cDNA 製品

      In lentiviral vector

      Granzyme H qPCR Primer (1)

      Granzyme H Lysate (1)

        Granzyme H の背景知識

        Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes (A-G and M) have been identified in the mouse, but only five are known in humans (A, B, H, M, and granzyme 3), and granzyme H appears to be specifically human. Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/natural?killer (NK) compartment of the immune system. In adenovirus-infected cells in which granzyme B (gzmB) and downstream apoptosis pathways are inhibited, granzyme H directly cleaves the adenovirus DNA-binding protein (DBP), a viral component required for viral DNA replication. This virus demonstrated that gzmH directly induces an important decay in viral DNA replication. Interestingly, gzmH also cleaves the adenovirus 1K assembly protein, a major inhibitor of gzmB, and relieves gzmB inhibition. Granzyme H has a very high amino acid identity (>9%) with many portions of the granzyme B sequence, particularly near the amino terminus of the molecule despite performing a distinct enzymic function.

        Granzyme H の参考文献

        • Meier M., et al.,(1990), Cloning of a gene that encodes a new member of the human cytotoxic cell protease family. Biochemistry 29:4042-4049.
        • Haddad P., et al., (1991), Structure and evolutionary origin of the human granzyme H gene.Int. Immunol. 3:57-66.
        • Klein J.L., et al.,(1990), Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C).Tissue Antigens 35:220-228.

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