Granzyme B Proteins, Antibodies, cDNA Clones Research Reagents

GZMB (Granzyme B, also known as C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1), located on 14q12, is a Protein Coding gene. The gene produces a 27716 Da protein composed of 247 amino acids. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance. Diseases such as Peripheral T-Cell Lymphoma and Severe Cutaneous Adverse Reaction are associated with GZMB.

Granzyme B Protein (1)

    Granzyme B Antibody (6)

      Granzyme B cDNA Clone (43)

      BC030195

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_004131.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_013542.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      Granzyme B Lysate (1)

        Granzyme B の背景知識

        Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.

        Granzyme B の参考文献

        • Schmid J., et al.,(1987), Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J. Immunol. 139:250-256.
        • Caputo A., et al., (1988), Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.J. Biol. Chem. 263:6363-6369.
        • Trapani J.A., et al.,(1988), Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.Proc. Natl. Acad. Sci. U.S.A. 85:6924-6928.

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