GPX1 (Glutathione Peroxidase 1) is a Protein Coding gene. The protein encoded by this gene belongs to the glutathione peroxidase family that catalyzes the reduction of hydrogen peroxide to water. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5, or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. GPX1 is the most abundant isoform and is expressed in all kidney cells. The GPX1 gene may play a critical role in the development of colorectal cancer. GPx1 played a significant role in regulating mechanical strain-induced POP.