GPT2 Proteins, Antibodies, cDNA Clones Research Reagents

GPT2 (Glutamic--Pyruvic Transaminase 2, also known as ALT2; GPT 2; MRT49; NEDSPM), located on 16q11.2, is a Protein Coding gene. The gene produces a 57904 Da protein composed of 523 amino acids. The protein contains the complete domain of transaminase class I and a partial domain of transaminase class II. GPT2 shares 69% identity with GPT, except that it is 27 amino acids longer. As a key enzyme for gluconeogenesis, GPT is a widely-used serum marker for liver injury. Diseases such as Mental Retardation, Autosomal Recessive 49, and Filarial Elephantiasis are associated with GPT2.

GPT2 Protein (1)

    GPT2 Antibody (4)

      GPT2 cDNA Clone (30)

      NM_133443.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001012057.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      GPT2 qPCR Primer (1)

      GPT2 Lysate (1)

        GPT2 の背景知識

        Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (Gpt), is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. As a key enzyme for gluconeogenesis, Gpt is a widely-used serum marker for liver injury. Two ALT isoenzymes have been identified, ALT1 and ALT2 (GPT1 and GPT2), which are encoded by separate genes and share significant sequence homology, but differ in their expression patterns. Gpt1 is widely distributed and mainly expressed in the intestine, liver, fat tissues, colon, muscle, and heart, in the order of high to low expression level, whereas Gpt2 expression is more restricted, mainly in the liver, muscle, brain, and white adipose tissue. It has been reported that hepatic ALT2 protein is approximately four times higher in male rats than in female rats.

        GPT2 の参考文献

        • Matthews, C.C. et al., 2002, Genomics. 79: 445-450.
        • Jadhao, S.B. et al., 2004, Hepatology. 39: 1297-1302.
        • Schindhelm, R.K. et al., 2005, Eur. J.Clin. Invest. 35:369-374.
        • Lindblom, P. et al., 2007, Arch Biochem Biophys. 466 (1): 66-77.
        • Liu, L.et al., 2008, Protein Expr Purif. 60 (2): 225-231.
        • Yang, R. Z. et al., 2009, Hepatology. 49 (2): 598-607.

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