GPR56 Proteins, cDNA Clones Research Reagents

ADGRG1 (Adhesion G Protein-Coupled Receptor G1, also known as BFPP; BPPR; GPR56; TM7LN4; TM7XN1), located on 16q21, is a Protein Coding gene. The gene produces a 77738 Da protein composed of 693 amino acids. The ADGRG1 protein shares 26 to 32% sequence identity with the 4 class B-like orphan receptors. Like these receptors, ADGRG1 contains 7 transmembrane domains, as well as a mucin-like domain and cysteine box in the N-terminal region. ADGRG1 plays a key role in cortical development. Diseases such as Polymicrogyria, Bilateral Frontoparietal, and Polymicrogyria, Bilateral Perisylvian, Autosomal Recessive are associated with ADGRG1.

GPR56 Protein (1)

    GPR56 cDNA Clone (52)

    NM_005682.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_011523468.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_018882.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_006530686.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    GPR56 Lysate (1)

      GPR56 の背景知識

      ADGRG1 (Adhesion G Protein-Coupled Receptor G1, also known as GPR56) is a Protein Coding gene. GPR56 is a member of an adhesion G protein-coupled receptor family with a very long N-terminal stalk and seven transmembrane domains. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. GPR56 may be a target for the treatment of type 2 diabetes. GPR56 inhibits melanoma metastatic growth by impeding the expansion of micrometastases to macrometastases. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Diseases associated with ADGRG1 include Polymicrogyria, Bilateral Frontoparietal, and Polymicrogyria, Bilateral Perisylvian, Autosomal Recessive.

      GPR56 の参考文献

      • Liu M., et al., 1999, Genomics 55: 296-305.
      • Huang,Y. et al., 2008, Mol Cell Biochem. 308 (1-2):133-9.
      • Li,S. et al., 2008, J Neurosci 28 (22):5817-26.
      • Jin,Z. et al., 2009, Prog Mol Biol Transl Sci. 89 :1-13.
      • Xu,L. et al., 2010, Clin Exp Metastasis. 27 (4):241-9.

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