gp130/IL6ST Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All gp130/IL6ST reagents are produced in house and quality controlled, including 22 gp130/IL6ST Antibody, 2 gp130/IL6ST ELISA, 52 gp130/IL6ST Gene, 10 gp130/IL6ST Lysate, 12 gp130/IL6ST Protein, 3 gp130/IL6ST qPCR. All gp130/IL6ST reagents are ready to use.

gp130/IL6ST Protein (12)

    gp130/IL6ST Antibody (22)

      gp130/IL6ST ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      gp130/IL6ST cDNA Clone (52)

      NM_002184.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010560.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001008725.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001100601.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      gp130/IL6ST Lysate (10)

        gp130/IL6ST の背景知識

        Glycoprotein 13 (also known as gp13, IL6ST, IL6-beta or CD13) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD13/gp13 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD13/gp13 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD13/gp13 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp13 for initiating signal transmission. CD13/gp13 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD13/gp13 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

        gp130/IL6ST の参考文献

        • Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
        • Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
        • Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.

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