GNRH2 Proteins, cDNA Clones Research Reagents

GNRH2 (Gonadotropin-Releasing Hormone 2, also known as GnRH-II; LH-RHII), located on 20p13, is a Protein Coding gene. The gene produces a 12918 Da protein composed of 120 amino acids. The predicted GNRH2 preprohormone is organized identically to that of other GNRHs: all have a signal sequence, followed by a GnRH decapeptide, a conserved proteolytic site (Gly-Lys-Arg), and a GNRH-associated peptide (GAP). Diseases such as Colon Mucinous Adenocarcinoma and Ovarian Cancer are associated with GNRH2. The related pathways of GNRH2 include Integrin Pathway and RET signaling.

GNRH2 Protein (1)

    GNRH2 cDNA Clone (13)

    BC069362

    クローニングベクター cDNA 製品

    In lentiviral vector

    GNRH2 qPCR Primer (1)

    GNRH2 Lysate (1)

      GNRH2 の背景知識

      GNRH2 (Gonadotropin-Releasing Hormone 2) is a Protein Coding gene. This gene is a member of the gonadotropin-releasing hormone (GnRH) gene family. Proteins encoded by members of this gene family are proteolytically cleaved to form neuropeptides which, in part, regulate reproductive functions by stimulating the production and release of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). 3 alternatively spliced human isoforms have been reported. The second mammalian isoform (GNRH2) is an ineffective stimulant of gonadotropin release. Given that pigs lack testicular GNRHR1, these data may indicate that GNRH2 and its receptor are involved in the autocrine or paracrine regulation of testosterone secretion. Diseases associated with GNRH2 include Colon Mucinous Adenocarcinoma and Ovarian Cancer.

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