G protein alpha S/GNAS Antibodies, cDNA Clones Research Reagents

GNAS (GNAS Complex Locus, also known as AHO; GSA; GSP; POH; GPSA; NESP; SCG6; SgVI; GNAS1; PITA3; C20orf45), located on 20q13.32, is a Protein Coding gene. GNAS is a complex imprinted locus that produces multiple transcripts through the use of alternative promoters and alternative splicing. The gene produces a 67948 Da protein composed of 626 amino acids. GNAS encodes the alpha-subunit of the stimulatory heterotrimeric G protein (Gsα), which belongs to the G-alpha family. GNAS mediates receptor-stimulated cAMP signaling, which integrates diverse environmental cues with intracellular responses.

G protein alpha S/GNAS Antibody (1)

    G protein alpha S/GNAS cDNA Clone (29)

    NM_080426.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_080425.3

    In expression vector

    NM_201616.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001159656.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    G protein alpha S/GNAS の背景知識

    GNAS (GNAS Complex Locus) is a Protein Coding gene. GNAS is a complex imprinted gene encoding the alpha-subunit of the stimulatory heterotrimeric G protein (Gs alpha), which belongs to the G-alpha family. Inactivating mutations in Gsalpha-coding GNAS exons are responsible for Albright's hereditary osteodystrophy (AHO), which refers to a constellation of physical and developmental disorders including obesity, short stature, brachydactyly, cognitive impairment, and heterotopic ossification. GNAS mediates receptor-stimulated cAMP signaling, which integrates diverse environmental cues with intracellular responses. GNAS mutations have been described in mucinous and non-mucinous epithelial neoplasms of the appendix, pancreas, and colon, with hotspot GNAS mutations found in up to two-thirds of pancreatic intraductal papillary mucinous neoplasms.

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