GNAS (GNAS Complex Locus) is a Protein Coding gene. GNAS is a complex imprinted gene encoding the alpha-subunit of the stimulatory heterotrimeric G protein (Gs alpha), which belongs to the G-alpha family. Inactivating mutations in Gsalpha-coding GNAS exons are responsible for Albright's hereditary osteodystrophy (AHO), which refers to a constellation of physical and developmental disorders including obesity, short stature, brachydactyly, cognitive impairment, and heterotopic ossification. GNAS mediates receptor-stimulated cAMP signaling, which integrates diverse environmental cues with intracellular responses. GNAS mutations have been described in mucinous and non-mucinous epithelial neoplasms of the appendix, pancreas, and colon, with hotspot GNAS mutations found in up to two-thirds of pancreatic intraductal papillary mucinous neoplasms.