GM2A Proteins, Antibodies, cDNA Clones Research Reagents

All GM2A reagents are produced in house and quality controlled, including 3 GM2A Antibody, 39 GM2A Gene, 1 GM2A IP Kit, 1 GM2A Lysate, 1 GM2A Protein, 1 GM2A qPCR. All GM2A reagents are ready to use.

GM2A Protein (1)

    GM2A Antibody (3)

      GM2A cDNA Clone (39)

      BC009273

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010299.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_003639011.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      GM2A qPCR Primer (1)

      GM2A Lysate (1)

        GM2A の背景知識

        GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB), also known as Tay-Sachs disease AB variant.

        GM2A の参考文献

        • Wright CS, et al. (2003) Structural analysis of lipid complexes of GM2-activator protein. J Mol Biol. 331(4):951-64.

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