Glypican 5 Proteins, cDNA Clones Research Reagents

GPC5 (Glypican 5), located on 13q31.3, is a Protein Coding gene. The gene produces a 63707 Da protein composed of 572 amino acids. GPC5 is a cell membrane protein that belongs to the glypican family. The properties of GPC5 make it an attractive target for therapeutic intervention in rhabdomyosarcomas and other tumors that amplify and/or overexpress its gene. The identity of GPC5 protein to GPC1 is 21%, and the identity to GPC3 is 40%. Diseases such as Omodysplasia and Tumoral Calcinosis, Hyperphosphatemic, Familial, 1 are associated with GPC5.

Glypican 5 Protein (1)

    Glypican 5 cDNA Clone (26)

    NM_004466.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_175500.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    Glypican 5 qPCR Primer (1)

    Glypican 5 Lysate (1)

      Glypican 5 の背景知識

      Glypican-5 (GPC5), is a cell membrane protein that belongs to the glypican family. The glypicans compose a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans that may play a role in the control of cell division and growth regulation. So far, six members (Glypican-1/GPC1, Glypican-2/GPC2, Glypican-3/GPC3, Glypican-4/GPC4, Glypican-5/GPC5, Glypican-6/GPC6) of this family are known in the vertebrates. In the adult, Glypican-5 is primarily expressed in the brain. It is also detected in the fetal brain, lung, and liver. Glypican-5 enhances the intracellular signaling of FGF2 and HGF. It alters the cellular distribution of FGF2. The properties of Glypican-5 make it an attractive target for therapeutic intervention in rhabdomyosarcomas and other tumors that amplify and/or overexpress its gene. Glypican-5 is overexpressed in lymphoma cell lines that had shown amplification. It is a likely target for amplification, and that over-expression of GPC5 may contribute to the development and/or progression of lymphomas and other tumors.

      Glypican 5 の参考文献

      • Yu W, et al. (2003) GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines. J Hum Genet. 48(6): 331-5.
      • Williamson D, et al. (2007) Role for amplification and expression of glypican-5 in rhabdomyosarcoma. Cancer Res. 67(1): 57-65.

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