Glyoxalase II/HAGH Proteins, Antibodies, cDNA Clones Research Reagents

HAGH (Hydroxyacylglutathione Hydrolase, also known as GLO2; GLX2; GLXII; HAGH1), located on 16p13.3, is a Protein Coding gene. The gene produces a 33806 Da protein composed of 308 amino acids. HAGH converts the intermediate substrate S-lactoyl-glutathione to reduced glutathione and D-lactate. HAGH belongs to the Metallo-beta-lactamase superfamily and is widely expressed in the kidney, liver, and other tissues. Diseases such as Hydroxyacyl Glutathione Hydrolase Deficiency are associated with HAGH. The related pathways of HAGH include Pyruvate metabolism and Citric Acid (TCA) cycle and Metabolism.

Glyoxalase II/HAGH Protein (1)

    Glyoxalase II/HAGH Antibody (3)

      Glyoxalase II/HAGH cDNA Clone (16)

      NM_001040427.1

      In expression vector

      NM_024284.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      Glyoxalase II/HAGH の背景知識

      HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. HAGH belongs to the Metallo-beta-lactamase superfamily. HAGH is widely expressed in the kidney, liver, and other tissues. Diseases associated with HAGH include Hydroxyacyl Glutathione Hydrolase Deficiency. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Metabolism. The human and rodent forms of glyoxalase II (HAGH) can readily be separated by starch gel electrophoretic procedures.

      Glyoxalase II/HAGH の参考文献

      • Mulley JC, et al. (1987). New regional localisations for HAGH and PGP on human chromosome 16. Hum Genet 74 (4): 423-4.
      • Rulli A, et al. (2001). Expression of glyoxalase I and II in normal and breast cancer tissues. Breast Cancer Res. Treat. 66 (1): 67-72.
      • Cordell PA, et al. (2004). The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II. J Biol Chem. 279 (27): 28653-61.

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