GLO1 Proteins, Antibodies, cDNA Clones Research Reagents

All GLO1 reagents are produced in house and quality controlled, including 3 GLO1 Antibody, 30 GLO1 Gene, 1 GLO1 IP Kit, 1 GLO1 Protein, 2 GLO1 qPCR. All GLO1 reagents are ready to use.

GLO1 Protein (1)

    GLO1 Antibody (3)

      GLO1 cDNA Clone (30)

      BC001741

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_025374.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      GLO1 の背景知識

      Lactoylglutathione lyase, also known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the glyoxalase I family. GLO1 / Glyoxalase I is a ubiquitous cellular defense enzyme involved in the detoxification of methylglyoxal, a cytotoxic byproduct of glycolysis. Accumulative evidence suggests an important role of GLO1 expression in protection against methylglyoxal-dependent protein adduction and cellular damage associated with diabetes, cancer, and chronological aging. GLO1 / Glyoxalase I has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. GLO1 / Glyoxalase I catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. GLO1 / Glyoxalase I exists in three separable isoforms which originate from two alleles in the genome. These correspond to two homodimers and one heterodimer composed of two subunits showing different electrophoretic properties. GLO1 upregulation may play a functional role in glycolytic adaptations of cancer cells.

      GLO1 の参考文献

      • Wu, YY. et al., 2008,Prog Neuropsychopharmacol Biol Psychiatry. 32 (7):1740-4.
      • Williams,R. et al., 2009, PLoS One  4 (3): e4649.
      • Antognelli,C. et al., 2009, BMC Cancer  9 :115.
      • Bair,W.B. et al., 2010, Melanoma Res  20 (2):85-96.

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