GLIPR1 Proteins, Antibodies, cDNA Clones Research Reagents

All GLIPR1 reagents are produced in house and quality controlled, including 2 GLIPR1 Antibody, 26 GLIPR1 Gene, 2 GLIPR1 Lysate, 2 GLIPR1 Protein, 2 GLIPR1 qPCR. All GLIPR1 reagents are ready to use.

GLIPR1 Protein (2)

    GLIPR1 Antibody (2)

      GLIPR1 cDNA Clone (26)


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      GLIPR1 Lysate (2)

        GLIPR1 の背景知識

        Glioma pathogenesis-related protein 1, also known as Protein RTVP-1, GLIPR1 and GLIPR, is a single-pass membrane protein which belongs to theCRISP family. GLIPR1 / RTVP-1 was expressed in high levels in glioblastomas, whereas its expression in low-grade astrocytomas and normal brains was very low. Transfection of glioma cells with small interfering RNAs targeting GLIPR1 / RTVP-1 decreased cell proliferation in all the cell lines examined and induced cell apoptosis in some of them. Overexpression of GLIPR1 / RTVP-1 increased astrocyte and glioma cell proliferation and the anchorage-independent growth of the cells. In addition, overexpression of GLIPR1 / RTVP-1 rendered glioma cells more resistant to the apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand and serum deprivation. GLIPR1 / RTVP-1 regulated the invasion of glioma cells was evident by their enhanced migration through Matrigel and by their increased invasion in a spheroid confrontation assay. The increased invasive potential of the GLIPR1 / RTVP-1 overexpressors was also shown by the increased activity of matrix metalloproteinase 2 in these cells. The expression of GLIPR1 / RTVP-1 is correlated with the degree of malignancy of astrocytic tumors and that GLIPR1 / RTVP-1 is involved in the regulation of the growth, survival, and invasion of glioma cells. GLIPR1 / RTVP-1 is a potential therapeutic target in gliomas.

        GLIPR1 の参考文献

        • Murphy E.V., et al., 1995, Gene. 159:131-5.
        • Rich T., et al., 1996, Gene. 180:125-30.
        • Rosenzweig,T. et al., 2006, Cancer Res. 66 (8):4139-48.

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