GLIPR1 Proteins, Antibodies, cDNA Clones Research Reagents

All GLIPR1 reagents are produced in house and quality controlled, including 2 GLIPR1 Antibody, 26 GLIPR1 Gene, 2 GLIPR1 Lysate, 2 GLIPR1 Protein, 2 GLIPR1 qPCR. All GLIPR1 reagents are ready to use.

GLIPR1 Protein (2)

    GLIPR1 Antibody (2)

      GLIPR1 cDNA Clone (26)

      NM_006851.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_028608.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      GLIPR1 Lysate (2)

        GLIPR1 の背景知識

        Glioma pathogenesis-related protein 1, also known as Protein RTVP-1, GLIPR1 and GLIPR, is a single-pass membrane protein which belongs to theCRISP family. GLIPR1 / RTVP-1 was expressed in high levels in glioblastomas, whereas its expression in low-grade astrocytomas and normal brains was very low. Transfection of glioma cells with small interfering RNAs targeting GLIPR1 / RTVP-1 decreased cell proliferation in all the cell lines examined and induced cell apoptosis in some of them. Overexpression of GLIPR1 / RTVP-1 increased astrocyte and glioma cell proliferation and the anchorage-independent growth of the cells. In addition, overexpression of GLIPR1 / RTVP-1 rendered glioma cells more resistant to the apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand and serum deprivation. GLIPR1 / RTVP-1 regulated the invasion of glioma cells was evident by their enhanced migration through Matrigel and by their increased invasion in a spheroid confrontation assay. The increased invasive potential of the GLIPR1 / RTVP-1 overexpressors was also shown by the increased activity of matrix metalloproteinase 2 in these cells. The expression of GLIPR1 / RTVP-1 is correlated with the degree of malignancy of astrocytic tumors and that GLIPR1 / RTVP-1 is involved in the regulation of the growth, survival, and invasion of glioma cells. GLIPR1 / RTVP-1 is a potential therapeutic target in gliomas.

        GLIPR1 の参考文献

        • Murphy E.V., et al., 1995, Gene. 159:131-5.
        • Rich T., et al., 1996, Gene. 180:125-30.
        • Rosenzweig,T. et al., 2006, Cancer Res. 66 (8):4139-48.

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