GFR Alpha-3/GFRA3 Proteins, Antibodies, cDNA Clones Research Reagents

All GFR Alpha-3/GFRA3 reagents are produced in house and quality controlled, including 5 GFR Alpha-3/GFRA3 Antibody, 39 GFR Alpha-3/GFRA3 Gene, 4 GFR Alpha-3/GFRA3 Lysate, 4 GFR Alpha-3/GFRA3 Protein, 2 GFR Alpha-3/GFRA3 qPCR. All GFR Alpha-3/GFRA3 reagents are ready to use.

GFR Alpha-3/GFRA3 Protein (4)

    GFR Alpha-3/GFRA3 Antibody (5)

      GFR Alpha-3/GFRA3 cDNA Clone (39)

      NM_001496.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010280.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001112630.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      GFR Alpha-3/GFRA3 Lysate (4)

        GFR Alpha-3/GFRA3 の背景知識

        Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA3 / GDNFRa3 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. The neurotrophic growth factor artemin binds selectively to GDNF family receptor α3 (GFRA3 / GDNFRa3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons.

        GFR Alpha-3/GFRA3 の参考文献

        • Widenfalk J, et al. (2000) Neurturin, RET, GFRalpha-1 and GFRalpha-2, but not GFRalpha-3, mRNA are expressed in mice gonads. Cell Tissue Res. 299(3): 409-15.
        • Li J, et al. (2009) Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice. FEBS Lett. 583(15): 2479-85.
        • Yang C, et al. (2006) Distribution of GDNF family receptor alpha3 and RET in rat and human non-neural tissues. J Mol Histol. 37(1-2): 69-77.

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