GDF5 Antibodies, cDNA Clones Research Reagents

All GDF5 reagents are produced in house and quality controlled, including 1 GDF5 Antibody, 15 GDF5 Gene, 2 GDF5 qPCR. All GDF5 reagents are ready to use.

GDF5 Antibody (1)

    GDF5 cDNA Clone (15)


    In expression vector

    In lentiviral vector


    クローニングベクター cDNA 製品

    In lentiviral vector

    GDF5 qPCR Primer (2)

    GDF5 の背景知識

    GDF5 (growth and differentiation factor five), a member of the TGF-beta superfamily, binds specifically to BMPR1b, BMPR2 and ACTR2a receptors forming a heterodimeric complex, thereby inducing phosphorylation of smad1, 5, 8 and translocation to the nucleus. Variants in GDF5 are associated with human arthritis and decreased height. The SNP causes GDF5 expression to be reduced and thus increases OA susceptibility. A CPC containing the novel GDF5 mutant BB-1 may thus represent an alternative to the bioinert, supraphysiologically stiff polymethylmethacrylate cement presently used to treat osteoporotic vertebral fractures by vertebroplasty and kyphoplasty.

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