GDF5 Antibodies, cDNA Clones Research Reagents

All GDF5 reagents are produced in house and quality controlled, including 1 GDF5 Antibody, 15 GDF5 Gene, 2 GDF5 qPCR. All GDF5 reagents are ready to use.

GDF5 Antibody (1)

    GDF5 cDNA Clone (15)

    BC032495

    In expression vector

    In lentiviral vector

    XM_001066344.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    GDF5 qPCR Primer (2)

    GDF5 の背景知識

    GDF5 (growth and differentiation factor five), a member of the TGF-beta superfamily, binds specifically to BMPR1b, BMPR2 and ACTR2a receptors forming a heterodimeric complex, thereby inducing phosphorylation of smad1, 5, 8 and translocation to the nucleus. Variants in GDF5 are associated with human arthritis and decreased height. The SNP causes GDF5 expression to be reduced and thus increases OA susceptibility. A CPC containing the novel GDF5 mutant BB-1 may thus represent an alternative to the bioinert, supraphysiologically stiff polymethylmethacrylate cement presently used to treat osteoporotic vertebral fractures by vertebroplasty and kyphoplasty.

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