GDF15 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All GDF15 reagents are produced in house and quality controlled, including 3 GDF15 Antibody, 2 GDF15 ELISA, 40 GDF15 Gene, 1 GDF15 Lysate, 2 GDF15 Protein, 1 GDF15 qPCR. All GDF15 reagents are ready to use.

GDF15 Protein (2)

    GDF15 Antibody (3)

      GDF15 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      GDF15 cDNA Clone (40)

      NM_004864.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001114375.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_541938.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      GDF15 qPCR Primer (1)

      GDF15 Lysate (1)

        GDF15 の背景知識

        Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.

        GDF15 の参考文献

        • Ago T, et al. (2006) GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res. 98 (3): 294-297.
        • Hsiao E, et al. (2000) Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol. 20 (10): 3742-51.
        • Zimmers T, et al. (2005) Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury. Shock. 23 (6): 543-8.

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