GCAP1 Proteins, Antibodies, cDNA Clones Research Reagents

GUCA1A (Guanylate Cyclase Activator 1A, also known as COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131), located on 6p21.1, is a Protein Coding gene. The gene produces a 22920 Da protein composed of 201 amino acids. GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). Diseases such as Cone Dystrophy 3 and Choroidal Dystrophy, Central Areolar, 1 are associated with GUCA1A.

GCAP1 Protein (2)

    GCAP1 Antibody (2)

      GCAP1 cDNA Clone (13)

      BC031663

      クローニングベクター cDNA 製品

      In lentiviral vector

      GCAP1 qPCR Primer (1)

      GCAP1 Lysate (2)

        GCAP1 の背景知識

        GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase-activating protein 1 (GCAP 1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP 1 promotes the activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in GCAP 1 gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. GCAP 1 stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in the recovery of the dark state of rod photoreceptors following light exposure.

        GCAP1 の参考文献

        • Surguchov A, et al. (1997) The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1). Genomics. 39(3):312-22.
        • Subbaraya I, et al. (1995) Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem. 269(49):31080-9.
        • Payne AM, et al. (1998) A mutation in guanylate cyclase activator 1A (GCAP 1) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1. Hum Mol Genet. 7(2):273-7.

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