GASP-1/WFIKKN2 Proteins, cDNA Clones Research Reagents

WFIKKN2 (WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 2) is a protein coding gene located on human chromosome 17q21.33. WFIKKN2 is also known as GASP-1, WFDC20B, hGASP-1 and WFIKKNRP. The human WFIKKN2 gene encodes a 63941 Da protein containing 576 amino acids. The WFIKKN2 protein is biasedly expressed in ovary and testis. WFIKKN2 is related to serine-type endopeptidase inhibitor activity and metalloendopeptidase inhibitor activity. WFIKKN1 is an important paralog of WFIKKN2 gene. WFIKKN2 is associated with some diseases, including Central Nervous System Leukemia and Space Motion Sickness.

GASP-1/WFIKKN2 Protein (1)

    GASP-1/WFIKKN2 cDNA Clone (13)

    NM_175575.5

    クローニングベクター cDNA 製品

    In lentiviral vector

    GASP-1/WFIKKN2 qPCR Primer (1)

    GASP-1/WFIKKN2 Lysate (1)

      GASP-1/WFIKKN2 の背景知識

      WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2, also known as Growth and differentiation factor-associated serum protein 1, WAP, follistatin, immunoglobulin, kunitz and NTR domain-containing-related protein, WFIKKN-related protein, WFIKKN2 and GASP1, is a secreted protein that belongs to the WFIKKN family. WFIKKN2 contains two BPTI/Kunitz inhibitor domains, one Ig-like C2-type (immunoglobulin-like) domain, one Kazal-like domain, one NTR domain and one WAP domain. WFIKKN2 is primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney. WFIKKN2 is a protease-inhibitor that contains multiple distinct protease inhibitor domains. It probably has serine protease- and metalloprotease-inhibitor activity. It inhibits the biological activity of mature myostatin, but not activin. WFIKKN2 protein binds mature GDF8/myostatin and myostatin propeptide and inhibits the biological activity of myostatin.

      GASP-1/WFIKKN2 の参考文献

      • Clark H.F.et al., 2003,Genome Res. 13:2265-70.
      • Hill J.J.et al., 2003, Mol. Endocrinol. 17:1144-54.
      • Kondás,K. et al., 2008, J Biol Chem  283 (35):23677-84.

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