GAS6 Proteins, cDNA Clones Research Reagents

All GAS6 reagents are produced in house and quality controlled, including 26 GAS6 Gene, 1 GAS6 Lysate, 1 GAS6 Protein, 1 GAS6 qPCR. All GAS6 reagents are ready to use.

GAS6 Protein (1)

    GAS6 cDNA Clone (26)

    NM_000820.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_019521.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    GAS6 qPCR Primer (1)

    GAS6 Lysate (1)

      GAS6 の背景知識

      The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor progression by regulating growth in many cancers. GAS6, expressed by osteoblasts in the bone marrow, plays a significant role in the regulation of PCa cell survival during chemotherapy, which will have important implications for targeting metastatic disease. The GAS6/TYRO3-AXL-MERTK (TAM) signaling pathway is essential for full and sustained platelet activation, as well as thrombus stabilization. Inhibition of this pathway decreases platelet aggregation, shape change, clot retraction, aggregate formation under flow conditions, and surface expression of activation markers. It had been show that GAS6 signaling regulates invasion, proliferation, chemotherapy-induced apoptosis of prostate cancer (PCa) cells, and GAS6 secreted from osteoblasts in the bone marrow environment plays a critical role in establishing prostate tumor cell dormancy.

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