Ferritin heavy chain 1/FTH1 Proteins, Antibodies, cDNA Clones Research Reagents

All Ferritin heavy chain 1/FTH1 reagents are produced in house and quality controlled, including 2 Ferritin heavy chain 1/FTH1 Antibody, 60 Ferritin heavy chain 1/FTH1 Gene, 1 Ferritin heavy chain 1/FTH1 Protein, 3 Ferritin heavy chain 1/FTH1 qPCR. All Ferritin heavy chain 1/FTH1 reagents are ready to use.

Ferritin heavy chain 1/FTH1 Protein (1)

    Ferritin heavy chain 1/FTH1 Antibody (2)

      Ferritin heavy chain 1/FTH1 cDNA Clone (60)

      NM_002032.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010239.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_012848.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001195380.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      Ferritin heavy chain 1/FTH1 の背景知識

      FTH1 (ferritin, heavy polypeptide 1) is the heavy subunit of ferritin which is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. FTH1 gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. FTH1 stores iron in a soluble, non-toxic, readily available form. It is important for iron homeostasis. It has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. It also plays a role in delivery of iron to cells. FTH1 mediates iron uptake in capsule cells of the developing kidney.

      Ferritin heavy chain 1/FTH1 の参考文献

      • Hentze MW, et al. (1986) Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene. Proc Natl Acad Sci. 83(19):7226-30.
      • Rual, et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature. 437(7062):1173-8.
      • Stelzl, et al. (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell. 122(6):957-968.

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