FNDC4 Proteins, Antibodies, cDNA Clones Research Reagents

All FNDC4 reagents are produced in house and quality controlled, including 1 FNDC4 Antibody, 26 FNDC4 Gene, 1 FNDC4 Lysate, 1 FNDC4 Protein, 2 FNDC4 qPCR. All FNDC4 reagents are ready to use.

FNDC4 Protein (1)

    FNDC4 Antibody (1)

      FNDC4 cDNA Clone (26)


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      FNDC4 Lysate (1)

        FNDC4 の背景知識

        FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, treatment with FNDC4 results in a state of dampened macrophage activity, while enhancing their survival. That FNDC4 may be a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.