Factor XII heavy chain Antibodies, cDNA Clones Research Reagents

All Factor XII heavy chain reagents are produced in house and quality controlled, including 1 Factor XII heavy chain Antibody, 16 Factor XII heavy chain Gene, 1 Factor XII heavy chain qPCR. All Factor XII heavy chain reagents are ready to use.

Factor XII heavy chain Antibody (1)

    Factor XII heavy chain cDNA Clone (16)

    BC012390

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_000505.4

    In expression vector

    NM_001014006.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    Factor XII heavy chain qPCR Primer (1)

    Factor XII heavy chain の背景知識

    Egress of vaccinia virus from its host cell is mediated by the microtubule-associated motor kinesin-1, and three viral proteins, A36 and the F12/E2 complex, have been implicated in this process. In the presence of the F12 protein, loss of kinesin-1 interaction made a greater contribution to plaque size than did the formation of actin tails. However in the absence of F12, the ability of A36 to promote egress was abrogated. Therefore, the ability of A36 to promote egress by kinesin-1 is reliant on the F12 protein. Hereditary angioedema with normal C1 esterase inhibitor and mutations in the F12 gene (HAE-FXII) is associated with skin swellings, abdominal pain attacks, and the risk of asphyxiation due to upper airway obstruction.

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