ERAP2 Proteins, cDNA Clones Research Reagents

All ERAP2 reagents are produced in house and quality controlled, including 13 ERAP2 Gene, 1 ERAP2 Lysate, 1 ERAP2 Protein, 1 ERAP2 qPCR. All ERAP2 reagents are ready to use.

ERAP2 Protein (1)

    ERAP2 cDNA Clone (13)


    クローニングベクター cDNA 製品

    In lentiviral vector

    ERAP2 qPCR Primer (1)

    ERAP2 Lysate (1)

      ERAP2 の背景知識

      Leukocyte-derived arginine aminopeptidase (LRAP), also known as endoplasmic reticulum-aminopeptidase 2 (ERAP2), is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum (ER) processing antigenic peptides presented to major histocompatibility complex (MHC) class I molecules. It is a 96-amino acid protein with significant homology to placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase. LRAP preferentially hydrolyzes the basic residues Arg and Lys, and contains the HEXXH(X)18E zinc-binding motif, which is the characteristic of the M1 family of zinc metallopeptidases which also includes PILS/ARTS1/ERAP1 and LNPEP/PLAP. Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors.

      ERAP2 の参考文献

      • Tanioka T., et al.,(2003), Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases. J. Biol. Chem. 278:32275-32283.
      • Tanioka T., et al., (2005), Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma.FEBS J. 272:916-928.
      • Liu T., et al.,(2005), Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.J. Proteome Res. 4:2070-2080.

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