ERAP2 Proteins, cDNA Clones Research Reagents

All ERAP2 reagents are produced in house and quality controlled, including 13 ERAP2 Gene, 1 ERAP2 Lysate, 1 ERAP2 Protein, 1 ERAP2 qPCR. All ERAP2 reagents are ready to use.

ERAP2 Protein (1)

    ERAP2 cDNA Clone (13)

    NM_022350.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    ERAP2 qPCR Primer (1)

    ERAP2 Lysate (1)

      ERAP2 の背景知識

      Leukocyte-derived arginine aminopeptidase (LRAP), also known as endoplasmic reticulum-aminopeptidase 2 (ERAP2), is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum (ER) processing antigenic peptides presented to major histocompatibility complex (MHC) class I molecules. It is a 96-amino acid protein with significant homology to placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase. LRAP preferentially hydrolyzes the basic residues Arg and Lys, and contains the HEXXH(X)18E zinc-binding motif, which is the characteristic of the M1 family of zinc metallopeptidases which also includes PILS/ARTS1/ERAP1 and LNPEP/PLAP. Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors.

      ERAP2 の参考文献

      • Tanioka T., et al.,(2003), Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases. J. Biol. Chem. 278:32275-32283.
      • Tanioka T., et al., (2005), Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma.FEBS J. 272:916-928.
      • Liu T., et al.,(2005), Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.J. Proteome Res. 4:2070-2080.

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