EphA1 Proteins, Antibodies, cDNA Clones Research Reagents

All EphA1 reagents are produced in house and quality controlled, including 3 EphA1 Antibody, 26 EphA1 Gene, 3 EphA1 Lysate, 3 EphA1 Protein, 2 EphA1 qPCR. All EphA1 reagents are ready to use.

EphA1 Protein (3)

    EphA1 Antibody (3)

      EphA1 cDNA Clone (26)

      NM_005232.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_023580.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      EphA1 Lysate (3)

        EphA1 の背景知識

        EPHA1 or EPH receptor A1 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. An important role of Eph receptors and their ligands ephrins is to mediate cell-contact-dependent repulsion. Eph receptors and ephrins also act at boundaries to channel neuronal growth cones along specific pathways, restrict the migration of neural crest cells, and via bidirectional signaling prevent intermingling between hindbrain segments. Eph receptors and ephrins can also trigger an adhesive response of endothelial cells and are required for the remodeling of blood vessels. Eph receptors and ephrins have emerged as key regulators of the repulsion and adhesion of cells that underlie the establishment, maintainence, and remodeling of patterns of cellular organization. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps.

        EphA1 の参考文献

        • Flanagan JG, et al. (1998) THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT. Annual Review of Neuroscience. 21: 309-45.
        • Wilkinson DG (2000) Eph receptors and ephrins: Regulators of guidance and assembly. International Review of Cytology. 196: 177-244.
        • Zhou R. (1998) The Eph family receptors and ligands. Pharmacol. 77 (3): 151-81.

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