EPCR Proteins, Antibodies, cDNA Clones Research Reagents

PROCR (Protein C Receptor) is a protein coding gene located on human chromosome 20q11.22. PROCR is also known as CCCA, EPCR and CCD41. The human PROCR gene encodes a 26671 Da protein containing 238 amino acids. The PROCR protein is ubiquitously expressed in placenta, fat and other tissues. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. PROCR is associated with some diseases, including Purpura Fulminans and Thrombophilia.

EPCR Protein (7)

    EPCR Antibody (18)

      EPCR cDNA Clone (41)

      BC014451

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_011171.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001025733.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001100647.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      EPCR Lysate (7)

        EPCR の背景知識

        Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found mainly near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depending on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other.

        EPCR の参考文献

        • Nicolaes GA, et al. (2003). Congenital and acquired activated protein C resistance. Semin Vasc Med. 3 (1): 33-46.
        • Esmon CT. ( 2003). The protein C pathway. Chest 124 (3): 26-32.
        • Mosnier LO, et al. (2007)The cytoprotective protein C pathway. Blood. 109: 3161-72.

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