EpCAM Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All EpCAM reagents are produced in house and quality controlled, including 21 EpCAM Antibody, 2 EpCAM ELISA, 40 EpCAM Gene, 4 EpCAM IP Kit, 8 EpCAM Lysate, 13 EpCAM Protein, 2 EpCAM qPCR. All EpCAM reagents are ready to use.

EpCAM Protein (13)

    EpCAM Antibody (21)

      EpCAM ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      EpCAM cDNA Clone (40)

      NM_002354.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008532.2

      クローニングベクター cDNA 製品

      NM_138541.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001040029.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      EpCAM qPCR Primer (2)

      EpCAM Lysate (8)

        EpCAM の背景知識

        Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â…transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

        EpCAM の参考文献

        • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
        • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
        • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
        • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.

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